MVSA techniques are statistical methods for examining large bodies of data and extracting knowledge. For example, when examining PEMFC (Proton Exchange Membrane Fuel Cell) – pre-use, fabricated, or post-mortem – by Raman spectroscopy, the methodology uses all the spectral information available and enables the extraction of relevant information by regression of the spectral data against the property data of interest, revealing trends often missed by simple analysis. This can allow rapid definition of the relevant features to properties of interest. It can also be used as a means of predicting and analysing properties in a non destructive method if a ‘calibration’ database can be built. Classic areas of interest include conductivity, water-uptake and state, mechanical strength, durability and lifetime, degradation mechanisms and migration effects.